Date & Location: 19 - 22 January 2010, Advanced Training Centre, EMBL Heidelberg, Germany

Event website & Registration: http://www.embl.de/courses/proteinarchitecture/2010

Registration deadline: 4 December 2009

Aims

Over the last few years a new paradigm has been emerging concerning the nature of Eukaryotic regulatory proteins - contrasting with the nice neat globular protein view expounded by biochemical and cell biological textbooks. Instead, many proteins have a remarkable number of architecture modules - including long natively disordered segments and short linear motifs that are awkward to investigate computationally and experimentally.

The course will set the scene by introducing the biological concepts behind these architecture modules and provide extensive hands-on application of the relevant bioinformatics tools with appropriate example proteins. The power - but also the limitations, which remain substantial - of the currently available software will be examined.

Topics

- Introduction to Common Bioinformatic Tools (optional initial half day at no extra cost)
- Multiple Sequence Alignment
- Protein-Protein Interaction Networks
- Predicting Globular Domains and Native Disorder
- Exploring Regulatory Protein Motifs
- 3D Structures of Proteins and Protein-Protein Interactions
- Bioinformatic Resource Integration

Instructors

Nigel Brown, University of Heidelberg, Germany
Ricardo Rodriguez De La Vega, EMBL, Heidelberg, Germany
Francesca Diella, Biobyte Solutions GmbH, Heidelberg, Germany
Niall Haslam, Complex and Adaptive Systems Laboratory, University College Dublin, Germany
Lars Juhl Jensen, Novo Nordisk Foundation Center for Protein Research, Denmark
Philip McDermott , University of Manchester, United Kingdom
Sean O'Donoghue, EMBL, Heidelberg, Germany
Steve Pettifer, University of Manchester, United Kingdom
Venkata Satagopam, EMBL, Heidelberg, Germany
Andrea Schafferhans-Fuhrmann, TU Muenchen, Germany
David Thorne, University of Manchester, United Kingdom


Tuesday, 19 January 2010
(Optional introductory topics - attendance at no additional cost)
13:30 - 14:00 Welcome Remarks
Toby Gibson and Aidan Budd
14.00 - 14.30 Introduction to Teaching Machines
Aidan Budd
14.30 - 15.30 Introduction to Bioinformatics Tools and Analyses:
Aidan Budd and Venkata Satagopam
15.30 - 16.00 Coffee Break
16.00 - 18.00 Sequence Database Similarity Searching (BLAST):
Nigel Brown

Wednesday, 20 January 2010
09:00 - 10:30 Introduction to Modular Protein Architecture:
Toby Gibson
10:30 - 11:00 Coffee Break
10.30 - 15.00 Multiple Sequence Alignment (including coffee and lunch)
Aidan Budd
15.00 - 15.30 Coffee Break
15.30 - 18.00 Protein-Protein Interaction Networks
Lars Juhl Jensen

Thursday, 21 January 2010
09.00 - 12.30 Predicting Globular Domains and Native Disorder
Niall Haslam
12.30 - 14.00 Lunch Break
14.00 - 16.30 Identifying Potential ELMs (including coffee)
Francesca Diella
16.30 - 18.00 Webservices/UTOPIA/CINEMA
Steve Pettifer, David Thorne and Philip McDermott
14:00 - 15:30 RNA Turnover
15:30 - 16:00 Coffee Break
16:00 - 17:30 RNA Turnover (cont)
17:30 - 19:30 Poster Session with Aperitif

Friday 22 January 2010
09.00 - 10:00 Exploring Protein Structure with SRS3D
Sean O'Donoghue and Andrea Schafferhans-Fuhrmann
10.00 - 12.30 Structures of Protein-Protein Interactions
Ricardo Rodriguez De La Vega
12.30 - 14.00 Lunch Break
14.00 - 16.30 Student Presentations

Organisers
Scientific Organisers

Aidan Budd, EMBL Heidelberg, Germany

Toby Gibson, EMBL Heidelberg, Germany
Conference Organiser

Adela Valceanu, EMBL Heidelberg, Germany

Registration and Payment

Registration deadline is 4 December 2009.

Registration Link: Academia incl. registration

Attendance Fee: 250 Euros including twin room accommodation (for 2 or 3 nights, depending whether you apply for the optional initial introductory half-day), meals, local transport and course material.

The number of participants is limited to 20.

After the registration deadline expired, a selection will take place and everybody will be informed about the outcome. After registering you will be asked to submit your motivation letter. This should contain a statement about current research and a justification of interest in the course. You can submit a motivation letter using the account you've created (email + password). The motivation letter submission link will be found in the confirmation page/ e-mail you will receive after registration.

Before submitting please take into consideration:

* The limit of 2000 characters refers to manually typed text.
* If you copy paste the text, hidden formatting might still be included and you will be informed that your text exceeds the limit of 2000 characters. We recommend copy-pasting it into Notepad and then onto the website.
* Some symbols are not recognized by the tool if they are copy-pasted. Make sure to use the website’s editing tool to include the special characters.
* If you still encounter problems, try changing the web browser.