Hyphenated separation methods have advanced significantly in the past decade and new solutions and improvements are continuously being developed, enormously expanding the possibilities of analytical science. As the complexity of a sample is frequently much higher than one could have imagined in the past, fully exploiting the potential of separation (chromatography, electrophoresis, etc.) and detection system (mass spectrometry, NMR, etc.) with a multidimensional approach has really unlocked the door to a more efficient investigation and structural elucidation of analytes in different fields, i.e. the study of biological processes, food science, environmental science, biomedical and pharmaceutical science, etc. Particularly, so called hyphenated dimensions, combining several techniques both in separation (multidimensional techniques) and detection (mass spectrometry, NMR, multiple detectors), are currently offering a powerful methodology for all the -omic sciences, in which targeting both the knowns and the unknowns is a fundamental requisite. An efficient management of the enormous amount of data currently extractable by a complex sample is another challenge in this field. Therefore, this special issue will be devoted to new developments, new technological achievements, as well as novel applications of hyphenated methods in separation sciences as key instruments to unravel the complexity.
Dr. Gianni Galaverna