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Constellation Pharmaceuticals and the Un 2013 : Constellation Pharmaceuticals and the University of Pittsburgh School of Medicine Receive Cystic Fibrosis Foundation Research Grant


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Constellation Pharmaceuticals and the University of Pittsburgh School of Medicine Receive Cystic Fibrosis Foundation Research Grant Press Release : Constellation Pharmaceuticals, Inc.  –  Thu, Oct 10, 2013 7:30 AM EDT
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Pharmaceuticals, Inc. , a clinical-stage biopharmaceutical company in
the field of epigenetics, today announced that it has been awarded a
research grant in collaboration with the University of Pittsburgh School
of Medicine from the Cystic Fibrosis Foundation to explore the potential
use of BET bromodomain inhibitors for the control of inflammation in
cystic fibrosis.
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“This research grant will facilitate the study of the epigenetic control
of inflammation, an area of active research at Constellation, in the
context of a disease for which the treatment options are very limited,”
commented Jose Lora, Ph.D., executive director of preclinical sciences
at Constellation.
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Through the grant, Constellation Pharmaceuticals will collaborate with
the laboratory of Jay Kolls, M.D., director, Richard King Mellon
Foundation Institute for Pediatric Research at Children’s Hospital of
Pittsburgh of UPMC, and professor of pediatrics and immunology at
University of Pittsburgh School of Medicine. Dr. Kolls’ laboratory is a
pioneer in the mechanistic understanding of cystic fibrosis, and has
made fundamental contributions to the concept of inflammation as a key
component of the pathophysiology of this disease.
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The research supported by this grant will test the preclinical efficacy
of novel anti-inflammatory compounds to reduce potential lung-damaging
inflammation in people with cystic fibrosis.
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The Cystic Fibrosis Foundation is the world's leader in the search for a
cure for cystic fibrosis and funds more cystic fibrosis research than
any other organization.
(b)About Constellation Pharmaceuticals(/b)
Constellation Pharmaceuticals leverages insights from the rapidly
expanding field of epigenetics to discover and develop small molecule
therapeutics for the treatment of cancer, inflammatory/immunologic
disorders and other diseases. The company’s innovative product discovery
engine targets both enzymes that modify the dynamic structure of
chromatin (writers and erasers) and other proteins that interact with
chromatin (readers) to control gene expression. Restoration of normal
gene expression through chromatin modulation by highly selective and
specific inhibitors promises to be a powerful avenue for the development
of important new medicines against a broad range of diseases. For more
information, please visit the company's website at .
(b)About the University of Pittsburgh School of Medicine(/b)
As one of the nation’s leading academic centers for biomedical research,
the University of Pittsburgh School of Medicine integrates advanced
technology with basic science across a broad range of disciplines in a
continuous quest to harness the power of new knowledge and improve the
human condition. Driven mainly by the School of Medicine and its
affiliates, Pitt has ranked among the top 10 recipients of funding from
the National Institutes of Health since 1998. In rankings recently
released by the National Science Foundation, Pitt ranked fifth among all
American universities in total federal science and engineering research
and development support.
Likewise, the School of Medicine is equally committed to advancing the
quality and strength of its medical and graduate education programs, for
which it is recognized as an innovative leader, and to training highly
skilled, compassionate clinicians and creative scientists well-equipped
to engage in world-class research. The School of Medicine is the
academic partner of UPMC, which has collaborated with the University to
raise the standard of medical excellence in Pittsburgh and to position
health care as a driving force behind the region’s economy. For more
information about the School of Medicine, see .
(b)About the Antonio J. and Janet Palumbo Cystic Fibrosis Center(/b)
The Antonio J. and Janet Palumbo Cystic Fibrosis Center (CF Center) at
Children's Hospital of Pittsburgh of UPMC is dedicated to providing
state-of-the-art care to patients and families with cystic fibrosis,
education for health care professionals, and conducting clinical and
basic research in cystic fibrosis. The program is accredited by the
Cystic Fibrosis Foundation for clinical care and research.
(b)About the Cystic Fibrosis Foundation(/b)
The Cystic Fibrosis Foundation is the world's leader in the search for a
cure for cystic fibrosis. The Foundation funds more cystic fibrosis
research than any other organization, and nearly every CF drug available
today was made possible because of Foundation support. Based in
Bethesda, Md., the Foundation also supports and accredits a national
care center network that has been recognized by the National Institutes
of Health as a model of care for a chronic disease. The Cystic Fibrosis
Foundation is a donor-supported nonprofit organization. For more
information, go to .
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