IEEE International Conference on Automation Science and Engineering (CASE) is the flagship automation conference of the IEEE Robotics and Automation Society and constitutes the primary forum for cross-industry and multidisciplinary research in automation. Its goal is to provide a broad coverage and dissemination of foundational research in automation among researchers, academics, and practitioners. IEEE CASE 2021 will be held in Lyon, France, on August 23-27, 2021. The theme of the conference is Data-Driven Automation.