Network of devices that includes the hardware, software, firmware, and actuators necessary for the devices to connect, communicate, and effectively share data through the Internet. The Internet of Things (IoT) attempts to connect “things,” such as machinery and items, to the Internet and, ultimately, to one another. IoT applications enable companies to avoid unplanned downtime, increase operating efficiency, spawn new products and services, and enhance risk management. Artificial Intelligence (AI) plays a growing role in IoT applications and deployments. IoT Safety and Security are important topics to ensure the operation of these smart applications. In addition, AI applications in this field must also be focused to increase the efficiency of technology solutions. By promoting novel, high-quality research findings and innovative solutions to challenging data science problems, the conference seeks to advance the state-of-the-art in IoT Safety and Security. Applications of these technologies in fields such as smart manufacturing, smart health, supply chain management, etc., will also be of interest at this conference. In particular, the industry 5.0 topic will be discussed through the keynote speaker’s presentation. As the fourth industrial revolution has passed an early stage of development, many companies are developing intelligent systems and cutting-edge innovations of Industry 4.0 to improve productivity and quality. Meanwhile, the next phase of industrialization has been started to introduce, known as Industry 5.0. One of the most prominent features of Industry 5.0 is that it places the well-being of humans at the center of the manufacturing process. Advanced technologies are also created to keep up with the trend of the fifth industrial revolution. AI algorithms have proven to play a key role in Industry 4.0. Moving to Industry 5.0, with the human-centric orientation, AI was developed in combination with human intelligence (HI), leading to the new concept of Augmented Intelligence (AuI). AI and AuI algorithms are expected to bring significant benefits in Industry 5.0. The difficulties, challenges, and perspectives for IoT Safety and Security in Industry 5.0 will be discussed in this conference.